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Clinical Trials

Our lead clinical studies cover various mechanisms of action including direct T-cell engagement, activation of immuno-inflammatory response and targeting tumor-associated stromal fibroblasts.

Psioxus Virus
Psioxus 2 Transgene

NG-350A Study
(FORTITUDE)

This study will evaluate the safety, tolerability and preliminary efficacy of NG-350A, either alone or in combination with pembrolizumab, in patients with advanced or metastatic epithelial tumors. 

Psioxus Virus
Psioxus 2 Transgene

NG-350A Study
(FORTIFY)

This study will evaluate the safety, tolerability and preliminary efficacy of NG-350A in combination with a checkpoint inhibitor, in patients with advanced or metastatic epithelial tumors.

Psioxus Virus
Psioxus 4 Transgene

NG-641 Study
(STAR)

The aim of this study is to characterise the safety, tolerability and preliminary efficacy of NG-641 in patients with metastatic or advanced epithelial tumors.

Psioxus Virus
Psioxus 4 Transgene

NG-641 Study
(MOAT)

The aim of this study is to characterise the safety and tolerability of neoadjuvant NG-641, as a monotherapy or in combination with pembrolizumab, in patients with surgically resectable squamous cell carcinoma of the head and neck (SCCHN). This study will also explore treatment outcomes and translational markers/assays of viral replication, transgene production and TME reprogramming.

Cartoon Virus 2.png
Psioxus 4 Transgene

NG-641 Study
(NEBULA)

This study will evaluate the safety, tolerability and preliminary efficacy of
NG-641 in combination with nivolumab, in patients with advanced or metastatic epithelial tumors.